1. First create an account on ZLOEmu (email and password from this site will be needed for authorization in ZClient).
2. Download and install ZClient instruction how to install ZClient
3. Download latest game version here http://factorio.su/en/
4. Download ZLoaderx64 and put it to game exe https://zloemu.tk/files/ZLoaderx64.exe
5. Launch ZClient and wait for successful authorization.
6. Run game with ZLoaderx64.exe
Login - your username, password - any.
If game restarts itself, after enable/disable mods for example, close it and run again with ZLoaderx64.exe